Investigador(a)

Alexies Dagnino

Filiación

Facultad de Ciencias, Universidad de Valparaíso.
Centro Interdisciplinario de Estudios en Salud, CIESAL.

 

Alexies Dagnino es neurobiólogo y profesor titular de la Universidad de Valparaíso. Estudió bioquímica en la Universidad Austral de Chile y luego obtuvo el grado de Doctor en Ciencias Biomédica en la Universidad de Chile. Ha realizado varias estadías de investigaciones donde se especializó en los efectos del estrés sobre la salud mental en la Stanford University (Salpolsky’s Lab, USA), University of Texas at Dallas (Atzori’s Lab, USA) y la University of Brighton (Flint’s Lab, UK). Desde el año 2011 es académico del Instituto de Fisiología de la Facultad de Ciencias. Su principal área de investigación es el estudio de las bases neurobiológicas de la resiliencia al estrés y su relación con el origen de enfermedades mentales como la depresión y los trastornos ansiosos.

 

Trabajos

Publicaciones en revistas científicas

Terreros G, Pérez MÁ, Muñoz-LLancao P, D’Espessailles A, Martínez EA, Dagnino-Subiabre A. The Neuroprotective Role of Quinoa (Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats. Nutrients. 2024 Jan 27;16(3):381. doi: 10.3390/nu16030381. PMID: 38337665; PMCID: PMC10857380.

Zúñiga-Hernández J, Farias C, Espinosa A, Mercado L, Dagnino-Subiabre A, Campo AD, Illesca P, Videla LA, Valenzuela R. Modulation of Δ5- and Δ6-desaturases in the brain-liver axis. Nutrition. 2025 Mar;131:112629. doi: 10.1016/j.nut.2024.112629. Epub 2024 Nov 12. PMID: 39642695.

Terreros G, Pérez MÁ, Muñoz-LLancao P, D’Espessailles A, Martínez EA, Dagnino-Subiabre A. The Neuroprotective Role of Quinoa (Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats. Nutrients. 2024 Jan 27;16(3):381. doi: 10.3390/nu16030381.

Escobar AP, Bonansco C, Cruz G, Dagnino-Subiabre A, Fuenzalida M, Negrón I, Sotomayor-Zárate R, Martínez-Pinto J, Jorquera G. Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologies. Int J Mol Sci. 2023 Jun 13;24(12):10083. doi: 10.3390/ijms241210083.

Rojas-Thomas F, Artigas C, Wainstein G, Morales JP, Arriagada M, Soto D, Dagnino-Subiabre A, Silva J, Lopez V. Impact of acute psychosocial stress on attentional control in humans. A study of evoked potentials and pupillary response. Neurobiol Stress. 2023 Jun 12;25:100551. doi: 10.1016/j.ynstr.2023.100551.

Burgueño AL, Astiz M, Dagnino-Subiabre A. Editorial: Early life stress and its impact on physiological fitness. Front Physiol. 2022 Oct 12;13:1037409. doi: 10.3389/fphys.2022.1037409.

Alvarado-Aravena C, Arriaza K, Castillo-Aguilar M, Flores K, Dagnino-Subiabre A, Estrada-Goic C, Núñez-Espinosa C. Effect of Confinement on Anxiety Symptoms and Sleep Quality during the COVID-19 Pandemic. Behav Sci (Basel). 2022 Oct 17;12(10):398. doi: 10.3390/bs12100398.

Dagnino-Subiabre A. Resilience to stress and social touch. Curr Opin Behav Sci. 2022 Feb;43:75-79. doi: 10.1016/j.cobeha.2021.08.011.

Bravo-Tobar ID, Fernández P, Sáez JC, Dagnino-Subiabre A. Long-term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats. J Neurosci Res. 2021 Oct;99(10):2493-2510. doi: 10.1002/jnr.24902.

Walker SC, Cavieres A, Peñaloza-Sancho V, El-Deredy W, McGlone FP, Dagnino-Subiabre A. C-low threshold mechanoafferent targeted dynamic touch modulates stress resilience in rats exposed to chronic mild stress. Eur J Neurosci. 2022 May;55(9-10):2925-2938. doi: 10.1111/ejn.14951.

Peñaloza-Sancho V, Pérez-Valenzuela C, Gonzalez C, Jujihara G, Bustos P, Dagnino-Subiabre A. Cannabinoid receptor type 1 modulates the effects of polyunsaturated fatty acids on memory of stressed rats. Nutr Neurosci. 2021 Aug;24(8):583-600. doi: 10.1080/1028415X.2019.1

Dagnino-Subiabre A. Stress and Western diets increase vulnerability to neuropsychiatric disorders: A common mechanism. Nutr Neurosci. 2021 Aug;24(8):624-634. doi: 10.1080/1028415X.2019.1661651.

Pérez MÁ, Morales C, Santander O, García F, Gómez I, Peñaloza-Sancho V, Fuentealba P, Dagnino-Subiabre A, Moya PR, Fuenzalida M. Ketamine-Treatment During Late Adolescence Impairs Inhibitory Synaptic Transmission in the Prefrontal Cortex and Working Memory in Adult Rats. Front Cell Neurosci. 2019 Aug 20;13:372. doi: 10.3389/fncel.2019.00372.

Pérez-Valenzuela C, Terreros G, Dagnino-Subiabre A. Effects of stress on the auditory system: an approach to study a common origin for mood disorders and dementia. Rev Neurosci. 2019 Apr 24;30(3):317-324. doi: 10.1515/revneuro-2018-0018.

Iturra-Mena AM, Arriagada-Solimano M, Luttecke-Anders A, Dagnino-Subiabre A. Effects of prenatal stress on anxiety- and depressive-like behaviours are sex-specific in prepubertal rats. J Neuroendocrinol. 2018 Jul;30(7):e12609. doi: 10.1111/jne.12609.

Jorratt P, Delano PH, Delgado C, Dagnino-Subiabre A, Terreros G. Difference in Perseverative Errors during a Visual Attention Task with Auditory Distractors in Alpha-9 Nicotinic Receptor Subunit Wild Type and Knock-Out Mice. Front Cell Neurosci. 2017 Nov 8;11:357. doi: 10.3389/fncel.2017.00357.

Pérez MÁ, Peñaloza-Sancho V, Ahumada J, Fuenzalida M, Dagnino-Subiabre A. n-3 Polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the hippocampus of stressed rats. Nutr Neurosci. 2018 Oct;21(8):556-569. doi: 10.1080/1028415X.2017.1323609.

Pérez-Valenzuela C, Gárate-Pérez MF, Sotomayor-Zárate R, Delano PH, Dagnino-Subiabre A. Reboxetine Improves Auditory Attention and Increases Norepinephrine Levels in the Auditory Cortex of Chronically Stressed Rats. Front Neural Circuits. 2016 Dec 27;10:108. doi: 10.3389/fncir.2016.00108.

Negrón-Oyarzo I, Dagnino-Subiabre A, Muñoz Carvajal P. Synaptic Impairment in Layer 1 of the Prefrontal Cortex Induced by Repeated Stress During Adolescence is Reversed in Adulthood. Front Cell Neurosci. 2015 Nov 12;9:442. doi: 10.3389/fncel.2015.00442.

Cruz G, Riquelme R, Espinosa P, Jara P, Dagnino-Subiabre A, Renard GM, Sotomayor-Zárate R. Neonatal exposure to estradiol valerate increases dopamine content in nigrostriatal pathway during adulthood in the rat. Horm Metab Res. 2014 May;46(5):322-7. doi: 10.1055/s-0033-1361159.

Negrón-Oyarzo I, Pérez MÁ, Terreros G, Muñoz P, Dagnino-Subiabre A. Effects of chronic stress in adolescence on learned fear, anxiety, and synaptic transmission in the rat prelimbic cortex. Behav Brain Res. 2014 Feb 1;259:342-53. doi: 10.1016/j.bbr.2013.11.001.

Proyectos

«Impact of the high n-6 polyunsaturated fatty acid intake and/or maternal obesity on neurodevelopment. Is there an essential contribution of dietary n-3 fatty acids?. IP Rodrigo Valenzuela, FONDECYT Regular N¬∫ 1221098. 2022-2025. Monto adjudicado: $ 267.840.000 pesos.

«Hyperandrogenism during prenatal and pubertal development alters functional brain networks compromising social cognition in daughters of women with polycystic ovary syndrome: a doble hit hypothesis».IP Nicolas Crisosto FONDECYT Regular N¬∫ 1210261. 2021-2024. Monto adjudicado: $ 266.319.555 pesos.

«Strategies for coping with stress during aging and its impact on memory». Alexies Dagnino (Investigador principal). Consorcio de Universidades del Estado (CUECH) RED21993. Grant N¬∫ CIES008 2023-2024. Monto adjudicado: $ 20.000.000 pesos. IP Alexies Dagnino

«Instituto Milenio para la investigación en depresión y desarrollo». Alex Behn (Director), Alexies Dagnino (Investigador Principal). Concurso Institutos Milenios 2025 (en concurso).

2023-2024. “Impact of stress resilience on cancer progression”. Global Fellowships Scheme, University of Brighton, UK. Grant Nº AP02 3010 G2452. Principal Investigator.

2022-2024. “Strategies for coping with stress during aging and its impact on memory”. Consorcio de Universidades del Estado (CUECH) RED21993. Grant Nº CIES008. Principal Investigator.

2022-2025. “Impact of the high n-6 polyunsaturated fatty acid intake and/or maternal obesity on neurodevelopment. Is there an essential contribution of dietary n-3 fatty acids?”. FONDECYT Regular Nº 1221098. Co-Investigator.

2021-2022. “Role of the glucocorticoid receptors on the long-term effects of stress resilience”. Puente-UV Grant Nº UVA20993. Principal Investigator.

2016-2019. “From presbycusis to dementia: a basic and clinical approach”. Anillo de Investigación en Ciencia y Tecnología grant Nº ACT1403. Principal Investigator.

2014-2018. “Effects of n-3 fatty acids and endocannabinoids on learning and auditory attention of chronically stressed rats”. FONDECYT Regular Nº 1141276. Principal Investigator.

2010-2014. “Effects of antidepressant and enriched environment treatments on the stress-induced impairment in the rat auditory system”. FONDECYT Regular Nº 1100413. Principal Investigator.

 

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