Javier Bracchiglione

Bracchiglione J, Meza N, Franco J, Escobar Liquitay CM, Novik A V, Ocara Vargas M, Lazcano G, Poloni D,Rinaldi Langlotz F, Roqué-Figuls M, Munoz SR, Madrid E. Semaglutide for adults living with obesity.Cochrane Database of Systematic Reviews TBD, Issue TBD. Art. No.: CD015092. DOI:10.1002/14651858.CD015092.pub2 (submitted).

Bracchiglione J, Meza N, Pieper D, Lunny C, Vargas-Peirano M, Vicuña J, Briceño F, Perez-Carrasco I, Urrútia G, Bonfill X, Madrid E. Impact of matrix-construction assumptions on the Corrected Covered Area: A Framework for Quantifying Overlap in Overviews of Systematic Reviews. Research Synthesis Methods (submitted).

Franco J, Guo Y, Varela LB, Aqra Z, Alhalahla M, Medina Rodriguez M, Salvador Oscco EL, Patiño Araujo B,Banda S, Escobar Liquitay CM, Bracchiglione J, Meza N, Madrid E. Tirzepatide for adults living withobesity. Cochrane Database of Systematic Reviews TBD, Issue TBD. Art. No.: CD016018. DOI:10.1002/14651858.CD016018. 101 (submitted).

Meza N, Bracchiglione J, Escobar Liquitay CM, Madrid E, Varela L, Guo Y, Urrútia G, Er S, Tiller S, Shokraee K, Alvarez Busco F, Solà I, Ocara Vargas M, Novik A V, Poloni D, Franco J. Liraglutide for adults living with obesity. Cochrane Database of Systematic Reviews TBD, Issue TBD. Art. No.: CD016017. DOI: 10.1002/14651858.CD016017 (submitted).

Escobar-Liquitay CM, Vergara-Merino L, Verdejo C, Kirmayr M, Schuller-Martínez B, Madrid E, Meza N, Bracchiglione J, Franco JVA. Methodological and users’ surveys on the use of the LILACS database in Cochrane reviews identified desirable improvements to the database. Health Info Libr J. 2024 Mar;41(1):76-83. doi: 10.1111/hir.12505. Epub 2023 Aug 13. PMID: 37574776.

Bracchiglione J, Alonso-Coello P. Clinical practice guidelines today: Moving in the right direction. Med Clin [Internet]. 2024 Feb 19; Available from: http://dx.doi.org/10.1016/j.medcli.2023.12.009

Javier Bracchiglione, Nicolás Meza, Carole Lunny, Dawid Pieper, Eva Madrid, Gerard Urrútia, Xavier Bonfill Cosp Assumptions for creating matrices of evidence to estimate overlap of primary studies in overviews of reviews: Protocol for a meta-research study medRxiv 2023.06.16.23291488; doi: https://doi.org/10.1101/2023.06.16.23291488

Meade A, Santero M, Savall-Esteve O, Bracchiglione J, Leache L, Selva A, Macias I, Cerdà P, Bonfill Cosp X. Immunotherapy or Targeted Therapy Versus Best Supportive Care for Advanced Gastric Cancer: A Systematic Review and Meta-analysis of Randomized Trials. J Gastrointest Cancer. 2025 Mar 4;56(1):75. doi: 10.1007/s12029-024-01155-y. PMID: 40032744; PMCID: PMC11876278.

Meza N, Bracchiglione J, Madrid E, Escobar Liquitay CM, Popova E, Salazar R, Urrútia G. Use of the patient-centered outcome Days Alive and Out of Hospital in clinical studies on perioperative care: a scoping review protocol. F1000Res [Internet]. 2024 Oct 10;13:1194. Available from: https://f1000research.com/articles/13-1194/v1

Requeijo C, Bracchiglione J, Meza N, Ribera P, Güell E, Bonfill Cosp X, Appropriateness of Systemic Oncological Treatments for Advanced Cancer (ASTAC) Research Group. Anti-cancer drugs versus supportive care for advanced biliary tract cancers: a systematic review. F1000Res [Internet]. 2024 Jun 7;13:599. Available from: https://f1000research.com/articles/13-599/v1

Roura S, Alvarez G, Hohenschurz-Schmidt D, Solà I, Núñez-Cortés R, Bracchiglione J, C Fernández-Jané, Phalip J, Gich I, Sitjà-Rabert M, Urrútia G. Lack of pragmatic attitude of self-labelled pragmatic trials on manual therapy: a methodological review. BMC Med Res Methodol [Internet]. 2024 Nov 11;24(1):273. Available from: http://dx.doi.org/10.1186/s12874-024-02393-1

55. Roura, G. Alvarez, D. Hohenschurz-Schmidt, I. Solà, R. Núñez-Cortés, J. Bracchiglione, C. Fernández-Jané, J. Phalip, I. Gich, M. Sitjà-Rabert, G. Urrútia, A call for improving the internal validity and the reporting of manual therapy trials self-labelled as pragmatic: A methodological review. International Journal of Osteopathic Medicine. 2025 Feb 7;55. doi: 10.1016/j.ijosm.2025.100754

Santero M, Meade AG, Selva A, Savall-Esteve O, Bracchiglione J, Macías I, Leache L, Cerdà P, Bonfill Cosp X, Appropriateness of Systemic Oncological Treatments for Advanced Cancer (ASTAC-Study) Research Group. Utilising systematic reviews to assess potential overtreatment and claim for better evidence-based research: an analysis of anticancer drugs versus supportive care in advanced esophageal cancer. Syst Rev [Internet]. 2024 Jul 18;13(1):186. Available from: https://dx.doi.org/10.1186/s13643-024-02594-1

Shang W, Hui X, Li M, Ren J, Huang X, Li J, Wang X, Wang Q, Ma Y, Madrid E, Bracchiglione J, Jiang L, Yang K, Yao L. Pharmacological treatments for adults with overweight and obesity without diabetes. Cochrane Database Syst Rev [Internet]. 2024 [cited 2024 Apr 19];(4). Available from: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015861/full

Bonfill Cosp X, Savall-Esteve O, Bracchiglione J, Requeijo C, Santero M; Appropriateness of Systemic Oncological Treatments for Advanced Cancer (ASTAC-Study) Research Group. Mismatch between evidence and related clinical recommendations about the treatment of advanced esophageal cancer patients with anticancer drugs: A critical historical review. J Cancer Policy. 2025 Jun;44:100580. doi: 10.1016/j.jcpo.2025.100580. Epub 2025 Mar 25. PMID: 40147630.

Bracchiglione J, Meza N, Pérez-Carrasco I, et al. A methodological review finds mismatch between overall and pairwise overlap analysis in a sample of overviews. J Clin Epidemiol. May 8 2023;159:31-39. doi:10.1016/j.jclinepi.2023.05.006

Bracchiglione J, Rodríguez-Grijalva G, Requeijo C, et al. Systemic Oncological Treatments versus Supportive Care for Patients with Advanced Hepatobiliary Cancers: An Overview of Systematic Reviews. Cancers (Basel). Jan 26 2023;15(3)doi:10.3390/cancers15030766

Cruzat B, Reveco-Guzmán K, Encina-Meneses M, Ortiz-Muñoz L, Bracchiglione J. Approaching the body of evidence: Key concepts of Overviews. Medwave. 2023 Jun 6;23(5). English, Spanish. doi: 10.5867/medwave.2023.05.2704. PMID: 37279463.

Escobar-Liquitay CM, Vergara-Merino L, Verdejo C, Kirmayr M, Schuller-Martínez B, Madrid E, Meza N, Bracchiglione J, Franco JVA. Methodological and users’ surveys on the use of the LILACS database in Cochrane reviews identified desirable improvements to the database. Health Info Libr J. 2023 Aug 13. doi: 10.1111/hir.12505. Epub ahead of print. PMID: 37574776.

Meza N, Madrid E, Bracchiglione J, Leyton F, Rojas V, Rada G, Verdugo F, Rojas AM, Peña J. Ministerio de Salud de Chile. Intervenciones no farmacológicas para abordar las necesidades de adolescentes con Trastorno del Espectro Autista (TEA)[Internet]. Santiago; 2023 Mar. Disponible en: https://etesa-sbe.minsal.cl/index.php/publicaciones/

Nino-de-Guzman E, Bracchiglione J, Vasquez-Mejia A, de Graaf G, Calderon CR, Alonso-Coello P. How do patients with Type 2 Diabetes Mellitus value the importance of outcomes? An overview of reviews. Value Health. Jul 27 2023;doi:10.1016/j.jval.2023.07.003

Niño-de-Guzman Quispe E, Bracchiglione J, Ballester M, et al. Patients’ and informal caregivers’ perspectives on self-management interventions for type 2 diabetes mellitus outcomes: a mixed-methods overview of 14 years of reviews. Arch Public Health. Aug 4 2023;81(1):140. doi:10.1186/s13690-023-01153-9

Salazar J, Bracchiglione J, Acosta-Dighero R, et al. Systemic oncological treatments in patients with advanced pancreatic cancer: a scoping review and evidence map. Support Care Cancer. Jan 9 2023;31(2):100. doi:10.1007/s00520-022-07564-8

Suzuki-Barrera K, Teramoto A, Sáez-Chandía J, Nakakuki K, Bracchiglione J. Oral Health Interventions in Natural Disasters: A Scoping Review. Disaster Med Public Health Prep. May 9 2023;17:e388. doi:10.1017/dmp.2023.62

Bracchiglione J, Meza N, Franco JVA, Escobar Liquitay CM, Munoz SR, Urrutia G, Madrid E. Mapping Chilean clinical research: a protocol for a scoping review and multiple evidence gap maps. BMJ Open [Internet]. 2022 Jun 20;12(6):e057555. Available from: http://dx.doi.org/10.1136/bmjopen-2021-057555

Bracchiglione J, Meza N, Madrid E Response to: ‘Additional considerations and response to Graphical Representation of Overlap for OVErviews (GROOVE tool)» Res Synth Methods. 2022 Jul 7. doi: 10.1002/jrsm.1588.

Bracchiglione J, Rodríguez-Grijalva G, Requeijo* C, Santero M, Salazar J, Salas-Gama K, Meade AG, Antequera A, Auladell-Rispau A, Quintana MJ, Solà I, Urrútia G, Acosta-Dighero R, Bonfill Cosp X. Systemic oncological treatments versus supportive care for patients with advanced hepatobiliary cancers: an overview of systematic reviews (submitted to Cancers journal)

Madrid E, Ocara Vargas M, Contreras-Vera C, Saldías C, Escobar Liquitay CM, Novik A V, Munoz SR, Bracchiglione J. Glucagon‐like peptide‐1 analogues for overweight or obese adults. Cochrane Database of Systematic Reviews 2022, Issue 9. Art. No.: CD015092. DOI: 10.1002/14651858.CD015092.

Matus V, Kirmayr M, Retamal C, Vergara-Merino L, Kotlik A, Pérez-Bracchiglione J*. Embolización de la arteria renal: Serie de casos y revisión de la literatura. Revista de Cirugía [Internet]. 2022 Feb 8 [cited 2022 Jul 2];74(1). Available from: https://revistacirugia.cl/index.php/revistacirugia/article/view/1172

Pérez-Bracchiglione, Javier; Meza, Nicolás; Bangdiwala, Shrikant; Niño de Guzmán, Ena; Urrútia, Gerard; Bonfill, Xavier; Madrid, Eva Graphical Representation of Overlap for OVErviews: GROOVE tool. Research Synthesis Methods March 2022 13(3): 381-388. DOI: 10.1002/jrsm.1557

Salas-Gama K, Díaz JM, Coronado J, Pérez-Bracchiglione J, Requeijo C, Samsó L, Suclupe S, Bolíbar I. Patient decision aids for adults with advanced chronic kidney disease with a medical recommendation to start dialysis: a scoping review protocol. JBI Evid Synth [Internet]. 2021 Jun 23;19(12):3347–54. Available from: http://dx.doi.org/10.11124/JBIES-20-00437

Salazar J, Bracchiglione J, Acosta-Dighero R, Meza N, Meade AG, Quintana MJ, Requeijo C, Rodríguez-Grijalva G, Santero M, Selva A, Solá I, Bonfill X. Systemic oncological treatments in patients with advanced pancreatic cancer: A scoping review and evidence map. (accepted in Supportive Care in Cancer)

Santero M, Pérez-Bracchiglione J, Acosta-Dighero R, Meade AG, Antequera A, Auladell-Rispau A, Quintana MJ, Requeijo C, Rodríguez-Grijalva G, Salas-Gama K, Dorantes-Romandia R, Salazar J, Solà I, Urrútia G, Bonfill Cosp X. Efficacy of systemic oncological treatments in patients with advanced esophageal or gastric cancers at high risk of dying in the middle and short term: an overview of systematic reviews. BMC Cancer [Internet]. 2021 Jun 16;21(1):712. Available from: http://dx.doi.org/10.1186/s12885-021-08330-5

Sgarbossa N, Ibáñez Cobaisse M, González Cianculli G, Bracchiglione J*, Franco JVA. Revisiones sistemáticas: conceptos clave para profesionales de la salud. Medwave. 2022 Oct 28. Available from: https://doi.org/10.5867/medwave.2022.09.2622

Stojanova J, Pérez-Bracchiglione J, Erridge S, Madrid E, Caracci B, Klabunde R, Franco JVA. Cannabis-based medicines for prevention of postoperative nausea and vomiting in adults (Protocol). Cochrane Database of Systematic Reviews 2022, Issue 2. Art. No.: CD014567. DOI: 10.1002/14651858.CD014567.

Suclupe S, Efrain Pantoja Bustillos P, Bracchiglione J, Requeijo C, Salas-Gama K, Solà I, Merchán-Galvis A, Uya Muntaña J, Robleda G, Martinez-Zapata MJ. Effectiveness of nonpharmacological interventions to prevent adverse events in the intensive care unit: A review of systematic reviews. Aust Crit Care [Internet]. 2022 Dec 24; Available from: http://dx.doi.org/10.1016/j.aucc.2022.11.003

Matus V, Kirmayr M, Retamal C, Vergara-Merino L, Kotlik A, Pérez-Bracchiglione J. Caracterización de los pacientes sometidos a embolización de arteria renal durante el período 2012-2020 en Valparaíso: Estudio descriptivo y revisión de la literatura. Rev. Cirugia. 2021;74(1).

Meza N, Pérez-Bracchiglione J, Pérez I, Carvajal C, Ortiz-Muñoz L, Olguín P, Rada G, Madrid E, COVID-19 L·OVE Working Group. Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers for COVID-19: A living systematic review of randomized clinical trials. Medwave 2021;21(2):e8105 Doi: 10.5867/medwave.2021.02.8105

Niño de Guzmán Quispe E, Martínez García L, Orrego Villagrán C, Heijmans M, Sunol R, Fraile-Navarro D, Pérez-Bracchiglione J, Ninov L, Salas-Gama K, Viteri García A, Alonso-Coello P. The Perspectives of Patients with Chronic Diseases and Their Caregivers on Self-Management Interventions: A Scoping Review of Reviews. Patient. 2021 Apr 19.

Núñez-Cortés R, Alvarez G, Pérez-Bracchiglione J, Cabanas-Valdés R, Calvo-Sanz J, Bonfill X, Urrutia G. Reporting results in manual therapy clinical trials: A need for improvement. Int J Osteopath Med [Internet]. 2021 Dec;42:92–9. Available from: https://linkinghub.elsevier.com/retrieve/pii/S1746068921000572

Papuzinski C, Loézar C, Carvajal N, Vargas M, Borgeat M, Madrid E, Perez-Bracchiglione J, Arancibia M Inclusion of evidence-based health in undergraduate programs in Chile and the integrated model Scientific Research Methodology-Evidence-Based Medicine at the University of Valparaíso Educación Médica Volume 22, Supplement 3, June 2021, Pages 179-184

Quilodrán C, Kirmayr M, Valente B, Pérez-Bracchiglione J, Garegnani L, Franco JVA. The GRADE approach, Part 2: Evidence to decision frameworks—outlining decision-making in health. April 2021 Medwave 21(4):e8182

Salazar J, Pérez-Bracchiglione J, Salas-Gama K, Antequera A, Auladell-Rispau A, Dorantes-Romandía R, Meade AG, Jesús Quintana M, Requeijo C, Rodríguez-Grijalva G, Santero M, Acosta-Dighero R, Solà I, Urrútia G, Bonfill Cosp X, Systemic Treatments for Advanced Digestive Cancer Research. Efficacy of systemic oncological treatments in patients with advanced pancreatic cancer at high risk of dying in the short or medium-term: overview of systematic reviews. Eur J Cancer [Internet]. 2021 Sep;154:82–91. Available from: http://dx.doi.org/10.1016/j.ejca.2021.05.034

Santero M, Pérez-Bracchiglione J, Acosta-Dighero R, Meade AG, Antequera A, Auladell-Rispau A, Quintana MJ, Requeijo C, Rodríguez-Grijalva G, Salas-Gama K, Dorantes-Romandia R, Salazar J, Solà I, Urrútia G, Bonfill Cosp X. Efficacy of systemic oncological treatments in patients with advanced esophageal or gastric cancers at high risk of dying in the middle and short term: an overview of systematic reviews. BMC Cancer. 2021 Jun 16;21(1):712. doi: 10.1186/s12885-021-08330-5. PMID: 34134661; PMCID: PMC8207789.

Schuller B, Meza N, Pérez-Bracchiglione J, Franco JVA, Loézar C, Madrid E. Graphical representation of the body of the evidence: the essentials for understanding the evidence gap map approach. April 2021 Medwave 21(3):e8164 DOI: 10.5867/medwave.2021.03.8164

Vargas-Peirano M, Verdejo C, Vergara-Merino L, Loézar C, Hoehmann M, Pérez-Bracchiglione J. Intravitreal antivascular endothelial growth factor in diabetic macular oedema: scoping review of clinical practice guidelines recommendations. Br J Ophthalmol [Internet]. 2021 Dec 14; Available from: http://dx.doi.org/10.1136/bjophthalmol-2021-319504

Vergara-Merino L, Meza N, Couve-Perez C, Carrasco C, Ortiz-Muñoz L, Madrid E, Bohorquez-Blanco S. Perez-Bracchiglione J. Maternal and perinatal outcomes related to COVID-19 and pregnancy  Acta Obstet Gynecol Scand. 2021 Feb 9. doi: 10.1111/aogs.14118.

Catalina Sofía Verdejo Cartagena, Laura Vergara Merino, Nicolás Meza Concha, Javier Pérez Bracchiglione, Natalia Carvajal Juliá, Eva Madrid Aris, Gabriel Rada Giacaman, María Ximena Rojas Reyes Macrolides for the treatment of COVID-19: A living systematic review. Medwave 2020;20(11):e8073 doi: 10.5867/medwave.2020.11.8073

Colomina MJ, Bago J, Perez-Bracchiglione J, Nishishinya Aquino MB, Salas KR, Requeijo C, et al. Thromboprophylaxis in elective spinal surgery: A protocol for systematic review. Medicine (Baltimore). 2020 May 22;99(21):e20127.

Loezar C, Pérez-Bracchiglione J, Arancibia M, Meza N, Vargas M, Papuzinski C, Rada G, Ondarza C, Jahr C, Cadena C, Madrid E. Guidelines in Low and Middle Income Countries Paper 2: Quality assessment of Chilean guidelines: need for improvement in rigor, applicability, updating, and patients’ inclusion. J Clin Epidemiol. 2020 Nov;127:177-183. doi: 10.1016/j.jclinepi.2020.07.018. Epub 2020 Aug 24. PMID: 32853762.

Meza N, Pérez-Bracchiglione J, Pérez I, Carvajal C, Olguín P, Rada G, Madrid E Angiotensin-converting-enzyme inhibitors and angiotensin II receptor blockers for COVID-19: A living systematic review protocol OSF 2020: DOI: 10.31219/osf.io/vp9nj

Niño de Guzmán E, Martínez García L, González AI, Heijmans M, Huaringa J, Immonen K, Ninov L, Orrego-Villagrán C, Pérez-Bracchiglione J, Salas-Gama K, Viteri-García A, Alonso-Coello P. The perspectives of patients and their caregivers on self-management interventions for chronic conditions: a protocol for a mixed-methods overview. F1000Res [Internet]. 2020 Feb 18;9:120. Available from: http://dx.doi.org/10.12688/f1000research.22125.2

Ricci-Cabello I, Vásquez-Mejía A, Canelo-Aybar C, Niño de Guzman E, Pérez-Bracchiglione J, Rabassa M, Rigau D, Solà I, Song Y, Neamtiu L, Parmelli E, Saz-Parkinson Z, Alonso-Coello P. Adherence to breast cancer guidelines is associated with better survival outcomes: a systematic review and meta-analysis of observational studies in EU countries. BMC Health Serv Res. 2020 Oct 7;20(1):920. doi: 10.1186/s12913-020-05753-x. PMID: 33028324; PMCID: PMC7542898.

Urrea G, Carvajal-Julia N, Arcos C, Perez-Bracchiglione J. Physicians perspectives about medical sources of information: protocol for an overview of systematic reviews. Medwave. 2020 Jun 9;20(5):e7921.

Vergara-Merino, L., Pérez-Bracchiglione, J., Meza, N., Couve, C., Carrasco, C., Ortiz-Muñoz, L. E., & Rada, G. (2020, July 30). Prognosis of COVID-19 in pregnancy: Protocol for an overview of systematic reviews. https://doi.org/10.31219/osf.io/64qyz

Madrid E, Barros Monge MJ, Urrútia G, Roqué i Figuls M, Pérez Bracchiglione J, Vargas Peirano M, Loézar Hernández CN, Bonfill Cosp X. Taxanes for advanced non-small cell lung cancer. Cochrane Database of Systematic Reviews 2018, Issue 7. Art. No.: CD013075. (WOS) . DOI: 14651858.CD013075.

World Health Organization – Multimodal clinical algorithms with GLP-1 RA or GLP-1/GIP dual agonists for the management of obesity in adults: a component-network meta-analysis.  Clinical Practice Guideline Obesity. World Health Organization Geneva. 2024-2025   (IP Juan Victor Ariel Franco).

World Health Organization –GLP-1 receptor agonists and GIP/GLP1 dual agonists for people with obesity. Clinical Practice Guideline Obesity. World Health Organization Geneva. 2024-2025   (IP Eva Madrid)

FONDECYT REGULAR 1212037 Mapping of Chilean clinical health research through a systematic approach for identifying evidence gaps: a step towards evidence-informed decision making and strategic research agendas. ANID-CONICYT (2021-2024) IP Eva Madrid

Proyecto. s/n, Commissioned Evidence Synthesis for the Gastroenteritis in Children Guideline project. KSA Task Force. Gabriel Rada.. 01/02/2022-01/05/2022. IP Gabriel Rada- Javier Bracchiglione, Eva Madrid y Nicolás Meza co-investigadores

«SERVICIOS DE ESTUDIO DE PAGO ASOCIADO A DIAGNÓSTICO EN ENFERMEDADES PROFESIONALES Asociaciones de Mutualidades de Chile, Rol: Investigador Principal»

Minsal ID 757-79-LP21   DIPLAS. Contratación de servicios de búsqueda, extracción de datos, evaluación de riesgo de sesgo y síntesis de evidencia científica para guías de práctica clínica GES (2021-2022) Ministerio de Salud Subsecretaría de Salud Pública SBEETESA. IP Eva Madrid, investigadores Nicolás Meza y Javier Bracchiglione

Minsal ID 757-79-LP21   DIPLAS. Contratación de servicios de búsqueda, extracción de datos, evaluación de riesgo de sesgo y síntesis de evidencia científica para guías de práctica clínica GES (2021-2022) Ministerio de Salud Subsecretaría de Salud Pública SBEETESA. Rol: Coordinadora Eva Madrid, investigadores Nicolás Meza y Javier Bracchiglione

Madrid E, Perez-Bracchiglione J, Rada G   DIPLAS. 00668. Resumen De Evidencia Sobre Estrategias Para El Control De La Fiebre “Q”. Ministerio de Salud SBE-ETESA 2018

Perez-Bracchiglione J, Bravo G, Madrid E, Meza N, Olguín P, Ortiz-Muñoz L, Arancibia M, Vergara L, Loézar C, Papuzinski C, Morel M, Villarroel C,   Resumen de Políticas: Evidencias para mejorar la tasa de vacunación del adulto Mayor Ministerio de Salud SBE-ETESA Financiamiento OPS 2018